Endocrine Abstracts

Background & Aim: Adrenocortical carcinoma (ACC) is an extremely rare malignancy usually with poor outcomes, although the prognosis varies greatly depending on the initial tumor stage. Here we present clinical and outcome diversity of the patients in a single center.Methods: We retrospectively analyzed 16 patients with ACC diagnosed between 2000 and 2022. Demographical findings, hormonal status, radiological findings, ENSAT stage, weiss score and Ki6...

Aim: Hypothyroidism is a common chronical disease worldwide, leading to a lifelong metabolic slowdown that can have a significant negative impact on the quality of life, both physiologically and psychologically. Despite achieving euthyroidism with replacement, there is evidence that symptoms persist. In this study, we aim to examine the effectiveness of thyroid hormone replacement and the effect of autoimmunity from a clinical-biochemical point of view by evaluating the euthyr...

Objective: It has been argued that salivary alpha-amylase (sAA) is a potential indirect sympathoadrenal medullary (SAM) system activity marker. This study aimed to look at sAA to assess the sympathetic nervous system in acromegaly patients.Subjects and Methods: A total of 31 individuals with acromegaly and 30 controls were enrolled in this prospective, single-center investigation. Saliva samples were taken from individuals with acromegaly and controls in...

Aim: Thyroid hormones have many effects on the cardiovascular system. May studies have showed that apparent or subclinical hypothyroidism increase the risk of hypertension hyperlipidemia and so lead to atherosclerosis susceptibility. This risk can be reduced by treatment. But, studies on the relationship between thyroid function tests and cardiovascular risk in euthyroid subjects are contradictory. This study was designed to investigate the effect of TSH, free T3, f...

Objective: The finding of new biomarkers is needed to have an early diagnosis of breast cancer. In this study we evaluated serum levels of carboxylated osteocalcin (OC) and uncarboxylated osteocalcin(UcOC), CRP as a diagnostic biomarker for breast cancer.Design and methods: Blood samples of 39 women with newly diagnosed breast cancer with stage I were obtained before surgery and 39 age and BMI matched health women were selected as controls.<p class="...

Aim: There are studies showing that Hashimoto’s thyroiditis (HT) progresses more rapidly, thyroid echogenicity is lower and thyroid autoantibodies are higher titer positive in immunoglobulin G4 (IGg4) positive patients.But a small number of studies that do not support this data have also been published.We planned this study to evaluate the findings of IgG4 (+) Hashimoto’s thyroiditis cases.Materials and methods: New diagnosis without treatment ...

Introduction: Hyperthyroidism is the condition that occurs due to excessive release of thyroid hormone by the thyroid gland. Anti-thyroid drugs are usually the first choice of the treatment but surgery and radioactive iodine can also be used in treatment of hyperthyroidism. Plasmapheresis is a rapid and effective treatment option in cases where immediate euthyroidism is needed to be obtained due to complications of thyrotoxicosis and major side effects of antithyroid drugs.</p...

Introduction: A diagnosis of subacute thyroiditis (SAT) is readily suspected when patients present with a particular set of typical clinical and laboratory characteristics. We present a patient with atypical SAT who had no neck pain but presented with fever, and weight loss; had thyrotoxicosis with normal 99mTc uptake, and needed higher doses of steroids to resolve.Case report: A 57-year-old man presented with a fever (39  °C) of 2 month-durati...

Background: Insulinoma is a rare tumour representing 1–2% of all pancreatic neoplasms and it is malignant in only 10% of cases. Locoregional invasion or metastases define malignancy, whereas dimension (> 2 cm), CK19 status, tumor staging and grading (Ki67 > 2%), and age of onset (> 50 years) can be considered elements of suspect.Case presentation: We report a case of malignant insulinoma in a 80 year old woman presenting symptoms c...

Familial glucocorticoid deficiency (FGD) is a rare autosomal recessive disorder characterised by unresponsiveness to ACTH and isolated cortisol deficiency. FGD is caused by mutations in genes encoding the ACTH receptor (melanocortin 2 receptor (MC2R)), its accessory protein (MRAP) or the steroidogenic acute regulatory protein (StAR). One significant feature is generalized skin hyperpigmentation which is thought to be due to elevated ACTH acting on the melanocortin 1 receptor (...